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    p57Kip2

    Gynecological Pathology
    ZR230 Rabbit Monoclonal

    Zeta p57Kip2 Antibody.    Zeta’s rabbit recombinant antibody recognizes p57Kip2, a protein of 57kDa with no cross-reaction with p27Kip1.  p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes and is a negative regulator of cell proliferation.

    Antibodies to p57 have been used as an aid in the identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain.  The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Colon carcinoma or placenta
    Visualization:Nucleus
    Isotype:IgG
    Immunogen:Recombinant full-length human p57Kip2 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2709RL
    Classification IVD
    Catalogue Number Z2709RL
    Package Inserts
    IFU-p57Kip2 ZR230 - IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS