Zeta OCT-4 Antibody. Zeta’s monoclonal mouse antibody recognizes OCT-4, a member of the POU family of transcription factors, is involved in regulating pluripotency during normal development, and is detectable in embryonic stem and germ cells. OCT-4 is a crucial regulator of self-renewal in embryonic stem cells; its expression is potentially correlated with tumorigenesis and can affect tumor recurrence or resistance to therapies. OCT-4 is expressed in undifferentiated pluripotent cells, germ cells in the ovary, and testes. The OCT-4 antibody is useful in the identification of primary as well as metastatic germ cell tumors.
Transcription factors containing the POU homeo domain have been shown to be important regulators of tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is additionally conferred at the dimerization level. OCT-3 (also known as OCT-4) is a mammalian POU transcription factor expressed by early embryo cells and germ cells. OCT-4 is essential for the identity of the pluripotential founder cell population in the mammalian embryo. A critical amount of OCT-4 is required to sustain stem-cell self-renewal, and up or down regulation induce divergent developmental programs. Two isoforms of Oct-3, termed OCT-3A and OCT-3B, are generated by alternative splicing.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.