Zeta p40 Antibody. Zeta’s recombinant rabbit antibody recognizes p40 (antibody recognizing ΔNp63 only), an isoform of p63 and thought to function as a stem cell factor that is responsible for maintaining cells in an uncommitted state with regenerative potential. This role for p40 may be recapitulated in tumors derived from these cells. p40 is usually expressed in the basal or progenitor cell layer of stratified epithelia (e.g., squamous, urothelial, bronchial), basal cells of some glandular epithelia (e.g., prostate), and myoepithelial cells of breast and salivary glands, trophoblasts and thymic epithelial cells. In tumor tissues, p40 expression is specific for squamous cell carcinoma. p40 is equivalent to p63 in sensitivity for lung squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. p40 appears to be a more reliable marker for squamous cell carcinoma
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