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    Nucleophosmin (NPM1)

    ZM82 Monospecific Mouse Monoclonal

    Recognizes a 33kDa glycoprotein, identified as nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody is a useful aid for classification of acute myeloid leukemia.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Isotype:IgG1 /κ
    Immunogen:Recombinant human NPM1 protein fragment (aa185-287)
    Ordering Information
    Classification IVD
    Catalogue Number Z2405ML
    Classification IVD
    Catalogue Number Z2405ML
    Package Inserts
    IFU-Nucleophosmin (NPM1) ZM82
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.