Human Ewing’s sarcoma stained with anti-NKX2.2 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells.
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Ewing's sarcoma
Visualization:Nuclear
Isotype:IgG1 /κ
Immunogen:Human recombinant NKX2.2 protein fragment (aa 1-119)
Ordering Information
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