MUC-1

    General & Epithelial Markers
    ZR435 Rabbit Monoclonal

    Zeta MUC-1 Antibody.  Zeta’s rabbit recombinant monoclonal antibody recognizes MUC-1, a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.  MUC-1 is expressed on the most secretory epithelium, including the mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over-expressed abundantly in >90% of breast carcinomas and metastases. Transgenic MUC-1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC-1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC-1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. The dominant epitope of this MUC-1 antibody has not yet been determined.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Breast carcinoma
    Visualization:Cytoplasmic
    Isotype:IgG
    Immunogen:Recombinant full-length human MUC1 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2791RL
    Classification IVD (Non-EU)/ RUO (EU)
    Catalogue Number Z2791RL
    Package Inserts
    IFU-MUC-1 ZR435 - IVD 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    IFU-MUC-1 ZR435 - RUO 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS