Human mesothelioma stained with anti-Mesothelin antibody using peroxidase-conjugate and DAB chromogen. Note membranous staining of tumor cells.

Mesothelin

Lung/Mediastinum Pathology

ZM25 Monospecific Mouse Monoclonal

Mesothelin is a 40kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Mesothelioma

Visualization:Cytoplasmic

Isotype:IgG2b /κ

Immunogen:Recombinant human mesothelin (MSLN) protein fragment (around aa 273-407)

Ordering Information

USA International

Package Inserts

IFU-Mesothelin ZM25

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

Accept Reject

SDS