Zeta Langerin Antibody. Zeta’s rabbit recombinant monoclonal antibody binds Langerin (CD207), a Ca2+-dependent, C-type lectin domain containing type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). Langerin is a highly selective marker for Langerhans cells and the lesional cells of Langerhans cell histiocytosis.
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess a strong immuno-stimulatory capacity and play a central role in initiating and regulating immune responses. BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. The human spleen, lymph node, thymus, liver, lung, and heart express Langerin protein.
Immunohistochemical evaluation of Langerin expression may have utility in substantiating a diagnosis of Langerhans cell histiocytosis and separating this disorder from other non-Langerhans cell histiocytic proliferations. Langerin protein expression has utility in differentiating Langerhans cell histiocytosis from other non-Langerhans cell histiocytic proliferations.
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