Preferred Clone
Human epithelioid sarcoma stained with anti-INI-1 antibody using peroxidase-conjugate and DAB. Note the absence of nuclear staining of tumor cells, whereas the background cells are positive.
The INI-1 gene (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1) is a protein that in humans is encoded by the SMARCB1 gene. The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. This gene has been found to be a tumor suppressor, which is often mutated or deleted in malignant rhabdoid tumors, epithelioid sarcoma, and some malignant peripheral nerve sheath (MPNST) tumors.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Epithelioid sarcoma
Visualization:Nuclear
Isotype:IgG
Immunogen:Full-length human BAF47 protein
Ordering Information
Package Inserts
SDS