Zeta FOXL2 Antibody. Zeta’s recombinant rabbit antibody recognizes FOXL2 (Forkhead Box L2), belongs to large family of forkhead FOX transcription factors. FOXL2 is a critical factor essential for ovary differentiation and maintenance and repression of the genetic program for somatic testis determination. FOXL2 is one of first genes expressed in female gonad development, required for proper granulosa cell differentiation during folliculogenesis. FOXL2 is expression is strongly maintained in granulosa cells throughout life.
FOXL2 prevents trans-differentiation of the ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. FOXL2 is mainly expressed in the ovary, parathyroid gland, and sex cord-stromal tumors.
The FOXL2 antibody is generally used to diagnose sex cord-stromal tumors along with inhibin, calretinin, and SF-1.
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