EP-CAM

    General & Epithelial Markers
    Ber-EP4 Mouse Monoclonal

    Zeta EP-CAM Antibody.  Zeta’s mouse monoclonal antibody recognizes EP-CAM (Epithelial Cellular Adhesion Molecule), which is expressed on basolateral cell surface in most simple epithelia and a vast majority of carcinomas.  EP-CAM is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA).  The EP-CAM antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. The EP-CAM antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.

    EP-CAM is normally expressed at the basolateral membrane of cells in the majority of epithelial tissues.  EP-CAM is not expressed in adult squamous epithelia, hepatocytes, myoepithelial cells, mesothelial cells or fibroblasts. EP-CAM is found in the large majority of adenocarcinomas of most sites (50-100%) in various studies; as well as neuroendocrine tumors, including small cell carcinoma. Renal clear cell carcinoma, renal oncocytoma and hepatocellular carcinoma stain in a minority of the cases, but papillary renal cell carcinoma, chromophobe renal cell carcinoma and cholangiocarcinoma stain at a higher percentage. Basal cell carcinoma is positive in almost all skin squamous carcinoma. EP-CAM can be of great help in the differentiating malignant involvement in the peritoneal and pleural cavities.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Colon carcinoma
    Visualization:Cytoplasmic
    Isotype:IgG1 /κ
    Immunogen:MCF-7 human breast carcinoma cell line
    Ordering Information
    Classification IVD
    Catalogue Number Z2314ML
    Classification IVD
    Catalogue Number Z2314ML
    Package Inserts
    IFU-EP-CAM Ber-EP4 -IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS