Zeta EP-CAM Antibody. Zeta’s mouse monoclonal antibody recognizes EP-CAM (Epithelial Cellular Adhesion Molecule), which is expressed on basolateral cell surface in most simple epithelia and a vast majority of carcinomas. EP-CAM is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA). The EP-CAM antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. The EP-CAM antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.
EP-CAM is normally expressed at the basolateral membrane of cells in the majority of epithelial tissues. EP-CAM is not expressed in adult squamous epithelia, hepatocytes, myoepithelial cells, mesothelial cells or fibroblasts. EP-CAM is found in the large majority of adenocarcinomas of most sites (50-100%) in various studies; as well as neuroendocrine tumors, including small cell carcinoma. Renal clear cell carcinoma, renal oncocytoma and hepatocellular carcinoma stain in a minority of the cases, but papillary renal cell carcinoma, chromophobe renal cell carcinoma and cholangiocarcinoma stain at a higher percentage. Basal cell carcinoma is positive in almost all skin squamous carcinoma. EP-CAM can be of great help in the differentiating malignant involvement in the peritoneal and pleural cavities.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.