Zeta EGFR Antibody. Zeta’s recombinant rabbit antibody recognizes EGFR, an important immunohistochemistry marker where high levels are found in squamous cell carcinoma and in adenocarcinomas, most strongly expressed on the tumor cell membrane. Increased levels of EGFR are linked to malignant transformation of squamous cells in carcinoma of the lung, head, neck, skin, cervix and esophagus.
This EGFR antibody recognizes a protein of 170kDa, identified as Epidermal Growth Factor Receptor. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. EGFR binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin, and epiregulin. EGFR is overexpressed in breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium tumors. EGFR is predominantly present in squamous cell carcinomas.