Zeta Collagen Type IV Antibody. Zeta’s recombinant mouse antibody recognizes Collagen Type IV, a major component of the basement membrane and plays an important role in cell adhesion, migration, differentiation and growth. Collagen Type IV express at the basement membranes in a variety of tissues including kidney, muscle, lymph nodes, lung, tendon and spleen. Collagen Type IV has been shown to be useful in differentiating microinvasive from in situ ductal carcinomas of the breast. Other Collagen Type IV studies include use in pancreatic adenocarcinoma and chronic pancreatitis, nephrosclerosis and other kidney diseases, oral squamous cell carcinoma, laryngeal cancers, ovarian cancers and cervical cancers.
Collagen Type IV is a type of collagen found primarily in the skin within the basement membrane zone. Collagen Type IV’s collagen C4 domain at the C-terminus is not removed in post-translational processing, and the fibers are thus link head-to-head, rather than in a parallel fashion. Collagen Type IV lacks a glycine in every third amino-acid residue necessary for the tight collagen helix. Overall Collagen Type IV conformation is structurally more pliable and kinked, relative to other collagen subtypes. These structural features allow Collagen Type IV to form sheets, which is the primary structural form found in the cutaneous basal lamina.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.