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    CD45RB (LCA)

    Hematopathology
    ZR361 Rabbit Monoclonal

    Zeta CD45RB Antibody.  Zeta’s recombinant rabbit antibody recognizes CD45RB (LCA), which is useful in the differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.  CD45 (PTPRC), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. According to cell type, multiple isoforms of CD45R are distributed throughout the immune system. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6), and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in the differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

    CD45RB is similar to CD45 although not expressed in Langerhans cells and some T-cells while B cells, most Tcells, monocytes, macrophages and ganulocytes exhibit weak expression.  Additionally, CD45RB is not expressed in platelets, plasma cell neoplams, some lymphoblastic lymphomas and some analaplastic large cell lympomas.  Finally, CD4+, CD45RB high T cells are present in inflammatory bowel disease and may be important in pathogenesis as they produce more proinflammatory cytokines than CD4+ CD45RB low T cells.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Tonsil or lymph node
    Visualization:Cell membrane
    Isotype:IgG
    Immunogen:Recombinant full-length human PTPRC protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2737RL
    Classification IVD
    Catalogue Number Z2737RL
    Package Inserts
    IFU-CD45RB ZR361
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS