Antibody CD4 Antibody. Zeta’s recombinant rabbit antibody recognizes CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. CD4 is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. CD4 serves as receptor for HIV.
CD4 is a glycoprotein belonging to immunoglobulin superfamily expressed on surface of T helper cells; serves as coreceptor in MHC class II-restricted antigen induced T cell activation. CD4+ CD25+ FOXP3+ regulatory T cells maintain peripheral tolerance and prevent autoimmunity and may be prognostic factor in malignancies. CD4 acts as an HIV receptor on T cells, macrophages and brain and is downregulated by HIV proteins during AIDS progression. CD4 is a common marker for T cells and is used to classify lymphomas and inflammatory conditions.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.