CD4

    Hematopathology
    ZR110 Rabbit Monoclonal

    Antibody CD4 Antibody.  Zeta’s recombinant rabbit antibody recognizes CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. CD4 is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. CD4 serves as receptor for HIV.

    CD4 is a glycoprotein belonging to immunoglobulin superfamily expressed on surface of T helper cells; serves as coreceptor in MHC class II-restricted antigen induced T cell activation.  CD4+ CD25+ FOXP3+ regulatory T cells maintain peripheral tolerance and prevent autoimmunity and may be prognostic factor in malignancies.  CD4 acts as an HIV receptor on T cells, macrophages and brain and is downregulated by HIV proteins during AIDS progression.  CD4 is a common marker for T cells and is used to classify lymphomas and inflammatory conditions.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Tonsil or cecum
    Visualization:Membrane
    Isotype:IgG
    Immunogen:A synthetic peptide corresponding to residues of human CD4 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2420RL
    Classification IVD
    Catalogue Number Z2420RL
    Package Inserts
    IFU-CD4 ZR110 - IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS