Preferred Clone
Formalin-Fixed, paraffin-embedded human thymus stained with anti-CD27 antibody using peroxidase-conjugate and DAB chromogen. Note the cell surface staining of medullary T cells
Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27. It is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NFkappa B and SAPK/JNK and induces apoptosis.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Thymus
Visualization:Cell surface
Isotype:IgG
Immunogen:Recombinant human CD27 protein fragment (aa 28-170)
Ordering Information
Package Inserts
IFU-CD27 ZR402 - IVD 0
SDS