AMACR + p63 + HMW CK Cocktail

    Urinary Pathology
    13H4 + ZM70 + 34βE12 Rabbit and Mouse Monoclonal

    AMACR is an essential enzyme in the b-oxidation of branched-chain fatty acids. High expression of AMACR protein is found in prostate adenocarcinoma but not in benign prostate tissue by immunohistochemical staining in paraffin-embedded tissue. The p63 protein, a homologue of the tumor-suppressor p53, is highly expressed in the basal or progenitor layer of many epithelial tissues. P63 is detected in prostate basal cells in normal prostate glands and PIN. However, it is negative in prostate adenocarcinoma. CK 34bE12 recognizes basal cells of benign prostate glands and PIN. Like p63, it is negative in prostate adenocarcinoma. Thus CK 34bE12 and p63 are useful as differential markers for benign prostate glands and adenocarcinoma (negative markers). The combination of AMACR, CK 34bE12 and p63 may be extremely useful for diagnosing PIN and small focus adenocarcinoma, especially in difficult cases and cases with limited tissues.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Prostate intraepithelial neoplasia (PIN)
    Visualization:Cytoplasmic and nuclear
    Isotype:IgG, IgG1 + IgG2a
    Immunogen:Human AMACR (P504S) , p63, and CKHMW (34βE12) polypeptides
    Ordering Information
    Classification IVD
    Catalogue Number Z2015MRL
    Classification IVD
    Catalogue Number Z2015MRL
    Package Inserts
    IFU-AMACR + p63 + HMW CK Cocktail 13H4 + ZM70 + 34βE12
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.