Zeta Tryptase Antibody. Zeta’s recombinant mouse antibody recognizes Tryptase, a family of trypsin-like serine proteases (peptidase family S1). Tryptase is stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptase is released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. The Zeta Tryptase antibody reacts with mast cells distributed in skin, synovium, lung, and heart. The Tryptase antibody does not bind with any other cell type. Human mast cell Tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. The Tryptase antibody, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.
The Tryptase antibody immunohistochemistry stains mast cells with an intense cytoplasmic granular staining pattern. The Tryptase antibody provides great utility diagnosing mast cell disease and detection of normal and neoplastic tissues.
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