Zeta TracP Antibody. Zeta’s recombinant mouse antibody recognizes TRAcP (tartrate-resistant acid phosphatase), a 35kDa protein that exists as two isoforms (5a and 5b). The Zeta TRAcP antibody reacts with both the isoforms. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption.
TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. TRAcP is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Zeta’s TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity in addition to macrophages and osteoclasts.
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