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    Thymidylate Synthase

    General & Epithelial Markers
    ZR245 Rabbit Monoclonal

    Zeta Thymidylate Synthase (TS) Antibody.  Zeta’s recombinant rabbit antibody recognizes Thymidylate Synthase (TS).  The antibody to Thymidylate Synthase (TS) recognizes a protein of 36kDa that converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), essential for DNA biosynthesis. Thymidylate Synthase (TS) is also a critical target for fluoropyrimidines, an essential antineoplastic drug widely used to treat solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP, which inactivates Thymidylate Synthase (TS) by forming a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of Thymidylate Synthase (TS) protein has been reported to associate with resistance to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:5-FU resistant cancer
    Visualization:Cytoplasmic
    Isotype:IgG1
    Immunogen:Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
    Ordering Information
    Classification IVD
    Catalogue Number Z2719RL
    Classification IVD
    Catalogue Number Z2719RL
    Package Inserts
    IFU-Thymidylate Synthase (TS) ZR245 - IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS