Human panceas stained with anti-SOX-9 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining of some glandular cells.

SOX-9

Neuropathology/Endocrine

ZM171 Monospecific Mouse Monoclonal

Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Human pancreas

Visualization:Nuclear

Isotype:IgG1 /κ

Immunogen:Recombinant human SOX9 protein fragment (around aa393-508)

Ordering Information

USA International

Package Inserts

IFU-SOX-9 ZM171

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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SDS