PSA

    Urinary Pathology
    ZR232 Rabbit Monoclonal

    Prostate-specific antigen (PSA) is a single-chain glycoprotein of 237 amino acids containing approximately 8% carbohydrate. It is a serine protease produced almost exclusively by prostatic epithelial cells. Immunohistochemically PSA is expressed in the highly specialized apically-superficial layer of female and male secretory cells of the prostate gland and is readily demonstrated in adenocarcinomas of the prostate in about 99% of the cases. There is a correlation between malignancy grade and intensity of staining, high-grade carcinomas displaying a weaker expression. About 1% of poorly differentiated carcinomas have been negative for PSA. Due to the high specificity of PSA for prostatic glandular epithelium, it is very useful in identifying prostatic carcinoma in the prostate and the adjacent organs often affected by epithelial malignancies, i.e., rectum and urinary bladder. PSA may be used in a panel with NKX3.1 and Prostein, which are at least as sensitive and slightly more specific than PSA.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Prostate
    Visualization:Cytoplasmic
    Isotype:IgG
    Immunogen:Recombinant fragment (around aa150-250) of human KLK3 protein (exact sequence is proprietary)
    Ordering Information
    Classification IVD
    Catalogue Number Z2710RL
    Classification RUO
    Catalogue Number Z2710RL-R
    Package Inserts
    IFU-PSA ZR232- IVD
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS