General & Epithelial Markers
    ZR3 Rabbit Monoclonal

    Programmed cell death ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog1 (B7-H1) is a type 1 transmembrane protein involved in the regulation of cellular and humoral immune responses. The interaction of PD-L1 with its receptor PD-1 provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy, tissue allografts, autoimmune disease and malignant transformation. The binding of PD-L1 to PD-1 induces apoptosis or exhaustion in activated T cells, and blockade of this interaction has been shown to enhance the antitumor activity of T cells. PD-L1 is frequently over expressed in placenta, and many human tumors such as melanoma, diffuse large B-cell lymphoma, and carcinomas of the lung, bladder, breast, kidney and colon.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Placenta or lung adenocarcinoma
    Immunogen:KLH-conjugated linear peptide corresponding tohuman PD-L1
    Ordering Information
    Classification IVD
    Catalogue Number Z2002RL
    Classification IVD
    Catalogue Number Z2002RL
    Package Inserts
    IFU-PD-L1 ZR3
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.