Mammaglobin Cocktail

    Breast Pathology
    304-1A5 & 31-A5 Mouse and Rabbit Monoclonal

    Zeta’s Mammoglobin cocktail includes recombinant antibody clones 304-1A5 and 31A5 and provides a highly sensititive and specific marker for breast carcinoma.  The Mammaglobin  clones 304-1A5/31A5 were raised against the full-length mammaglobin antigen and combined in a “cocktail” to detect the mammoglobin antigen in ductal and lobular epithelial cells.

    In normal breast tissue, 304-1A5 and 31A5 labels breast ductal and lobular epithelial cells. In tumor cells, it is reactive with all types of breast adenocarcinoma regardless tumor differentiation and types.  Adenocarcinomas from other organs rarely express mammaglobin.  The cellular localization of mammoglobin is cytoplasmic.

    Mammaglobin is a breast-associated glycoprotein distantly related to secretoglobin family that includes human uteroglobin and lipophilin. Unlike other secretoglobin family members, mammaglobin mRNA expression is breast specific, which has been shown to be a very sensitive marker of occult breast cancer cells in sentinel lymph nodes and peripheral blood.

    By paraffin immunohistochemistry, the overall sensitivity of mammaglobin for breast cancers was reported about 80%. When combined with other breast-restricted markers such as GCDFP-15, an overall sensitivity of 84% could be achieved . Mammaglobin can play a contributing role in the identification of primary sites of carcinomas presenting at metastatic sites.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Normal or neoplastic breast tissue
    Visualization:Cytoplasmic
    Isotype:Mouse IgG1/κ /Rabbit IgG
    Immunogen:Recombinant full-length protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2011MRL
    Classification IVD
    Catalogue Number Z2011MRL
    Package Inserts
    IFU-Mammaglobin Cocktail 304-1A5 & 31-A5
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS