Related Products

    INI-1

    Soft Tissue Pathology
    ZR282 Rabbit Monoclonal

    Zeta INI-1 Antibody.  Zeta’s recombinant rabbit antibody recognizes INI-1, a core subunit of the adenosine triphosphate (ATP) dependent SWI and SNF chromatin remodeling complex, which is actively involved in the regulation of gene expression. The INI-1 gene has been found to be a tumor suppressor, which is often mutated or deleted in malignant rhabdoid tumors, epithelioid sarcoma, and some malignant peripheral nerve sheath (MPNST) tumors.

    The INI-1 protein (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1) encoded by the SMARCB1 gene. The INI-1 protein is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively.

    The INI-1 is a tumor supressor where loss of function is associated with rhabdoid tumor predisposition syndrome 1 and familial schwannomatosis and has been identified in a variety of rhabdoid and nonrhabdoid neoplasms of the CNS, soft tissue and parenchymal and visceral organs.  Additionally, INI-1 loss of expression contributes to malignant rhabdoid tumor of kidney and soft tissue and CNS atypical teratoid or rhabdoid tumor and renal medullary carcinoma.  INI-1 loss of function is found in sinonasal carcinoma or adenocarcinoma and undifferentiated and rhabdoid carcinoma of the gastrointestinal tract and pancreas.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Epithelioid sarcoma
    Visualization:Nuclear
    Isotype:IgG
    Immunogen:Full-length human BAF47 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2597RL
    Classification IVD
    Catalogue Number Z2597RL
    Package Inserts
    IFU-INI-1 ZR282
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS