Zeta IgM Antibody. Zeta’s recombinant rabbit antibody recognizes IgM, a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. The antibody to IgM does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane-bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels of IgM are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom’s macroglobulinemia, chronic infection, and hepatocellular disease. This IgM antibody is useful in identifying leukemias, plasmacytomas, and certain non-Hodgkin’s lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltration is clonal and therefore malignant.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.