Zeta HSP70 Antibody. Zeta’s rabbit recombinant monoclonal antibody recognizes HSP70. HSP70 is an intronless gene encoding a 70kDa heat shock protein, a member of the heat shock protein 70 families. In conjunction with other heat shock proteins, HSP70 stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and organelles. HSP70 is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The HSP70 gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes that encode similar proteins.
HSP70 is an anti-apoptotic regulator promoting cell survival and is implicated in tumorigenesis. In hepatocytic tumors, HSP70 expression increases stepwise as a lesion progresses from precancerous to advanced HCC (74% sensitive and 98% specific for HCC on resection specimens or 48% and 94% on biopsy specimens). HSP70 is localized to nucleocytoplasmic and may be focal or diffuse (DNA mismatch repair proteins: scientific update and practical guide | Journal of Clinical Pathology (bmj.com)).