HSP70

Zeta’s rabbit recombinant monoclonal antibody recognizes HSP70.  HSP70 is an intronless gene encoding a 70kDa heat shock protein, a member of the heat shock protein 70 families. In conjunction with other heat shock proteins, HSP70 stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and organelles. HSP70 is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The HSP70 gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes that encode similar proteins.