Zeta HPV-Infected Tumor Cocktail – DUAL STAIN.
Zeta’s HPV-Infected Tumor Cocktail provides dual staining for p16 INK4a and Ki-67 in HPV-related tumors, offering unique value in assessing oncogenic transformation, cell cycle dysregulation, and tumor behavior, particularly in HPV-associated squamous cell carcinomas.
Zeta’s recombinant antibody cocktail contains two defined monoclonals that recognize specific proteins that help assess the prognosis for tumors that have been shown to have previous HPV-infection. p16 INK4a is a tumor suppressor protein involved in the pathogenesis of a variety of malignancies, and is expressed in the nucleoplasm of proliferating cells, functioning as an inhibitor of CDK4. Tumors infected with HPV, particularly the high-risk stains, express high level of P16 protein. The Ki-67 nuclear antigen is associated with cell proliferation. It is found throughout the cell cycle in the G1, S, G2, and M phases; but not the (G0) phase. It is commonly used to grade proliferation rates of tumors. An optimized antibody cocktail for p16 INK4a and Ki-67 is useful in the identification of tumor cells co-expressing both tumor suppression marker P16 (red) and cell proliferation marker Ki-67 (brown) in HPV infected tumors, such as high-grade dysplasia and carcinomas.
Zeta’s DUAL STAIN products provide more information from limited tissues, by seeing two related markers on the same slide while also allowing pathologists to see cellular localization and interaction within the tumor environment. Zeta uses one mouse and one rabbit recombinant monoclonal in each cocktail to allow for differential color results.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.