Her-2 Neu

    Breast Pathology
    ZR218 Rabbit Monoclonal

    Zeta Her-2/Neu Antibody.  Zeta’s recombinant rabbit antibody recognizes Her-2/Neu (Human epidermal growth factor receptor 2), a transmembrane growth factor receptor that regulates cell growth and survival that is routinely assessed in all primary invasive breast cancer and metastatic/recurrent breast cancer to inform eligibility for anti-HER2 directed targeted therapy.  HER-2/Neu is an oncogenic driver with negative prognostic impact in breast cancer.  HER-2/Neu testing identifies tumors that may respond to anti-HER2 directed targeted therapy.

    The Zeta Her-2/Neu recognizes a protein of 185kDa also known as c-erbB-2 and s a member of the EGFR family.  The Her-2/Neu antibody epitope is localized in the extracellular domain. This Her-2/Neu antibody is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of the EGFR family are located on the plasma membrane and consist of an extracellular ligand-binding domain connected to a large intracellular domain by a single transmembrane sequence. HER-2/Neu signaling activates multiple major signaling pathways (Ras, Raf, MEK, MAPK and PI3K,AKT) that promote cellular proliferation and antiapoptosis.  HER-2/Neu gene amplification results in HER-2/Neu protein overexpression.  HER-2/Neu protein is over-expressed in various carcinomas, especially the breast and ovary.  HER-2/Neu alteration and dysregulation drives breast cancer progression.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Breast carcinomas
    Visualization:Cell membrane
    Isotype:IgG
    Immunogen:Recombinant protein encoding extracellular domain of human c-erbB2
    Ordering Information
    Classification ASR
    Catalogue Number Z2499RL-A
    Classification RUO
    Catalogue Number Z2499RL-R
    Package Inserts
    IFU-Her-2/neu ZR218 ASR-0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    IFU-Her-2/neu ZR218 -RUO-0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS