Zeta HBsAG Antibody. Zeta’s recombinant rabbit antibody recognizes Hepatitis B surface antigen (HBsAg), a glycoprotein on the surface of the hepatitis B virus. After hepatitis B infection, HBsAg appears as the first viral marker. Using the HBsAg antibody, HBsAg can be detected in blood, saliva, breast milk, sweat, tears, nasopharyngeal secretions, semen, and vaginal secretions of patients 2 to 6 months after infection with HBV. HBsAg antibodies are mainly used for the diagnosis of the hepatitis B virus.
HBsAg is a multifunctional glycoprotein composed of large (LHB), middle (MHB), and small (SHB) subunits. HBsAg isoforms have numerous biological functions during HBV infection—from initial and specific viral attachment to the hepatocytes to initiating chronic infection with their immunomodulatory properties.
Hepatitis B surface antigen (HBsAg) is typically detectable after hepatitis B virus (HBV) infection, which is a risk factor of hepatocellular carcinoma (HCC). HBsAg expression is detected in positive patients not detected in negative patients, and the overall survival of the positive group was worse than negative group (Expression of hepatitis B surface antigen in liver tissues can serve as a predictor of prognosis for hepatitis B virus-related hepatocellular carcinoma patients after liver resection – PMC (nih.gov)).