Glutamine Synthetase

    GI Pathology
    ZM377 Mouse Monoclonal

    Zeta Glutamine Synthetase Antibody.  Zeta’s recombinant mouse antibody recognizes Glutamine Synthetase (GS), which forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. The Glutamine Synthetase enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of Glutamine Synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of Glutamine Synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine Synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of Glutamine Synthetase has been shown in primary liver cancers, indicating a potential role for Glutamine Synthetase in hepatocyte transformation.  Glutamine Synthetase (GS) is strongly expressed in a majority of hepatocellular carcinoma, including cases of early HCC and low grade HCC.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Normal liver
    Visualization:Cytoplasmic
    Isotype:IgG2b/κ
    Immunogen:Recombinant fragment (around aa 50-250) of human GLUL protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2668ML
    Classification IVD
    Catalogue Number Z2668ML
    Package Inserts
    IFU-Glutamine synthetase ZM377- IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS