Zeta Gastrin Antibody. Zeta’s recombinant mouse antibody recognizes Gastrin, a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. Gastrin also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms: G34 and G17. The Gastrin peptides activate two different receptors: the CCK-1 receptor, which has low affinity for Gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both Gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of Gastrin. More recently, Gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. The Gastrin antibody stains G-cells of human antral/pyloric mucosa and cells producing Gastrin or a structural gastrin analog as is seen in stomach; no staining of other cells or tissue types has been observed. The Gastrin antibody may react with sulfated and non-sulfated forms of Gastrin.
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