Zeta Factor VIII-R Antibody. Zeta’s recombinant mouse antibody recognizes Factor VIII-R (Factor VIII related antigen or von Willebrand factor), a multimeric glycoprotein that mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. Factor VIII-R has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Factor VIII-R (von Willebrand factor) is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. As not all endothelial cells synthesize or store this molecule, about 30% of tumors of vascular origin fail to stain for Factor VIII-R, regardless of whether they are benign or malignant. Staining for Factor VIII-R has also been used to measure angiogenesis, an indicator of tumor recurrence. Zeta’s Factor VIII-R antibody reacts specifically with the endothelial cells of normal, reactive, and neoplastic blood and lymphatic vessels and shows a finely granular cytoplasmic staining. The Factor VIII-R antibody also reacts with endocardium, platelets, and megakaryocytes.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.