Related Products

    Factor VIII-R

    Vascular Markers
    ZM64 Mouse Monoclonal

    Zeta Factor VIII-R Antibody.  Zeta’s recombinant mouse antibody recognizes Factor VIII-R (Factor VIII related antigen or von Willebrand factor), a multimeric glycoprotein that mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII.  Factor VIII-R has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Factor VIII-R (von Willebrand factor) is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. As not all endothelial cells synthesize  or store this molecule, about 30% of tumors of vascular origin fail to stain for Factor VIII-R, regardless of whether they are benign or malignant.  Staining for Factor VIII-R has also been used to measure angiogenesis, an indicator of tumor recurrence. Zeta’s Factor VIII-R antibody reacts specifically with the endothelial cells of normal, reactive, and neoplastic blood and lymphatic vessels and shows a finely granular cytoplasmic staining. The Factor VIII-R antibody also reacts with endocardium, platelets, and megakaryocytes.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Tonsil
    Visualization:Cytoplasmic
    Isotype:IgG1 /κ
    Immunogen:Recombinant fragment of human vWF protein (aa 1815-1939)
    Ordering Information
    Classification IVD
    Catalogue Number Z2393ML
    Classification IVD
    Catalogue Number Z2393ML
    Package Inserts
    IFU-Factor VIII-R ZM64 - IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS