Cytokeratin 8/18

    General & Epithelial Markers
    B22.1 & B23.1 Mouse Monoclonal

    Zeta Cytokeratin 8/18 Antibody.  Zeta’s mouse monoclonal antibodies (B22.1/B23.1) recognize Cytokeratin 8/18, which stains all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract, and urogenital tract including transitional epithelium.  Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). The Cytokeratin 8/18 antibody recognizes all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract, and urogenital tract including transitional epithelium. All adenocarcinomas and most squamous carcinomas are positive but keratinizing squamous carcinomas are usually negative. The Cytokeratin 8/18 antibody is useful in demonstrating the presence of Paget cells; there is very little keratin 18 in the normal epidermis so only Paget cells are stained.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Skin, breast carcinoma
    Visualization:Cytoplasmic
    Isotype:IgG1 /κ + IgG1 /κ
    Immunogen:Cytokeratins purified from breast cancer MCF-7 cells
    Ordering Information
    Classification IVD
    Catalogue Number Z2252ML
    Classification IVD
    Catalogue Number Z2252ML
    Package Inserts
    IFU-Cytokeratin 8/18 B22.1 & B23.1
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS