General & Epithelial Markers
    ZM121 Monospecific Mouse Monoclonal

    Cyclin E belongs to the highly conserved cyclin family; whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Colon carcinoma
    Isotype:IgG2b /κ
    Immunogen:Recombinant human Cyclin E (CCNE1) protein fragment (around aa 10-176)
    Ordering Information
    Classification IVD
    Catalogue Number Z2431ML
    Classification IVD
    Catalogue Number Z2431ML
    Package Inserts
    IFU-Cyclin-E ZM121
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.