Zeta CD22 Antibody. Zeta’s recombinant mouse antibody binds to CD22, which is expressed on normal and neoplastic B cells and is absent from other haemopoietic cell types. The CD22 antibody recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 is not expressed by plasma cells, but CD22 is found highly expressed in follicular mantle and marginal zone B-cells while germinal center B-cells are relatively weak in expression. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. CD22 also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.