CD22

    Hematopathology
    ZM183 Monospecific Mouse Monoclonal

    Zeta CD22 Antibody.  Zeta’s recombinant mouse antibody binds to CD22, which is expressed on normal and neoplastic B cells and is absent from other haemopoietic cell types.  The CD22 antibody recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+.  CD22 is not expressed by plasma cells, but CD22 is found highly expressed in follicular mantle and marginal zone B-cells while germinal center B-cells are relatively weak in expression. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes.  CD22 also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Lymph node
    Visualization:Cytoplasmic
    Isotype:IgG1 /κ
    Immunogen:Recombinant human BL-CAM/CD22 protein fragment (around aa 52-178)
    Ordering Information
    Classification IVD
    Catalogue Number Z2496ML
    Classification IVD
    Catalogue Number Z2496ML
    Package Inserts
    IFU-CD22 ZM183
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS