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    CA125 (MUC16)

    Gynecological Pathology
    ZM53 Mouse Monoclonal

    Zeta CA125 (MUC16) Antibody.  Zeta’s mouse recombinant antibody recognizes CA125 (MUC16).  The mucins (including CA125/MUC16) are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs). Membrane-associated and secretory Mucins such as CA125/MUC16 are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. Epithelial Mucins are large, secreted and cell surface glycoproteins crucial for adhesion modulation, signaling and epithelial cell protection. The number of repeats is highly polymorphic and varies among different alleles. The Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), Mucins 6-8, Mucins 11-13 and Mucins 15-17. The Mucin 16 (MUC16/CA125) protein, encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal domain. Mucin 16 (MUC16/CA125), an ovarian cancer-associated antigen, is a marker to monitor the progress of epithelial ovarian cancer.  CA125/MUC16 is a hydrophilic membrane-associated protein that may be involved in vitamin A functions.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Ovarian carcinoma
    Visualization:Extracellular membrane-associated
    Isotype:IgG1 /κ
    Immunogen:Full length native CA125 protein purified from human ovarian carcinoma
    Ordering Information
    Classification IVD
    Catalogue Number Z2363ML
    Classification IVD
    Catalogue Number Z2363ML
    Package Inserts
    IFU-CA 125/ MUC16 ZM53
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS