Soft Tissue Pathology
    ZR391 Rabbit Monoclonal

    The T-box gene family comprises members with a unique DNA binding domain. The best characterized T-box (Tbx) gene, brachyury or T, encodes a transcription factor that plays a vital role in early vertebrate development. Tbx genes are a family of developmental regulators with more than 20 members recently identified among invertebrates and vertebrates. Mutations in Tbx genes have been found to cause several human diseases. The understanding of functional mechanisms of Tbx products has come mainly from the prototypical T/brachyury protein, a transcription activator. The T-domain is a highly conserved DNA-binding motif originally defined in brachyury and characteristic of the Tbx family of transcription factors. The murine brachyury (T) gene is required in posterior mesoderm formation and axial development. Mutant embryos lacking T gene function are deficient in notochord differentiation and posterior mesoderm formation but develop anterior mesoderm.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Immunogen:Recombinant fragment (around aa 235-435) of human TBXT protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2747RL
    Classification IVD
    Catalogue Number Z2747RL
    Package Inserts
    IFU-Brachyury ZR390
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.