Zeta Beta-Catenin Antibody. Zeta’s mouse recombinant IVD antibody recognizes Beta-Catenin, which associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, Beta-Catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, Beta-Catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of Beta-Catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of Beta-Catenin and E-cadherin helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic Beta-Catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.