BCL-2

    Hematopathology
    ZR130 Rabbit Monoclonal

    Zeta BCL-2 Antibody.  Zeta’s recombinant rabbit antibody recognizes BCL-2 (B Cell Lymphoma 2), a protoncogene mainly localized to inner mitochondrial membrane, endoplasmic reticulum and nuclear envelope.  BCL-2 encodes a 25 kDa protein.  BCL-2 prevents cells from undergoing apoptosis and may participate in ion channel formation and alteration of membrane permeability, necessary for initiation of apoptosis.  Non-phosphorylated BCL-2 inhibits apoptosis, and Bax homodimers normally cause apoptosisB where Bax can bind to and inhibit non-phosphorylated BCL-2, promoting apoptosis.  BCL-2 overexpression in osteoblasts causes osteocyte apoptosis.  BCL-2 overexpression increase lifespan of B cells and may maintain memory B cells, plasma cells and neurons by prolonging life span without cell division.

    BCL-2 can distinguish follicular hyperplasia of lymph node from follicular lymphoma.  BCL-2 is usually overexpressed in follicular lymphoma, which brings BCL-2 gene adjacent to active immunoglobulin heavy chain gene.  Follicular lymphomas are BCL-2 negative.  BCL-2 can detect immature enteric ganglion cells in pediatric intestinal pseudo-obstruction.  BCL-2 may have prognostic value in early stage breast cancer.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Tonsil or lymph node
    Visualization:Cytoplasmic
    Isotype:IgG
    Immunogen:A synthetic peptide, aa 41-54 (GAAPAPGIFSSQPG-Cys) of human bcl-2 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2682RL
    Classification IVD
    Catalogue Number Z2682RL
    Package Inserts
    IFU-BCL-2 ZR130 - IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS