Human breast adenocarcinoma stained with anti-ER antibody using peroxidase-conjugate and DAB chromogen. Note the strong nuclear staining of tumor cells.

ER

Breast Pathology

ZM319 Mouse Monoclonal

Recognizes a protein of 67kDa, which is identified as estrogen receptor (ER) alpha. The ER gene consists of more than 140kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally discrete domains, labeled A through F. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to antiestrogen (e.g. tamoxifen) therapy.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Breast carcinoma

Visualization:Nuclear

Isotype:IgG1/K

Immunogen:Synthetic peptide corresponding to residues on the C-terminus of human E

Ordering Information

USA International

Package Inserts

IFU-ER ZM319 - IVD

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

Accept Reject

IFU-ERZM319 - ASR

Regulatory Notice

Accept Reject

SDS