ZAP-70

    Hematopathology
    ZM97 Monospecific Mouse Monoclonal

    ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Tonsil, CLL/SLL
    Visualization:Cytoplasmic
    Isotype:IgG1 /κ
    Immunogen:Recombinant fragment of human ZAP70 protein (around aa247-382)
    Ordering Information
    Classification IVD
    Catalogue Number Z2407ML
    Classification IVD
    Catalogue Number Z2407ML
    Package Inserts
    IFU-ZAP-70 ZM97
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS