Preferred Clone

Human tonsil stained with anti-ZAP-70 antibodies using peroxidase-conjugate and DAB chromogen. Note the positive staining of perifollicular B-cells

ZAP-70

Hematopathology

ZM97 Monospecific Mouse Monoclonal

ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Tonsil, CLL/SLL

Visualization:Cytoplasmic

Isotype:IgG1 /κ

Immunogen:Recombinant fragment of human ZAP70 protein (around aa247-382)

Ordering Information

USA International

Package Inserts

IFU-ZAP-70 ZM97

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

Accept Reject

SDS