Preferred Clone

Formalin-Fixed, paraffin-embedded human tonsil stained with anti-ZAP-70 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of B cells

ZAP-70

Hematopathology

ZR410 Rabbit Monoclonal

ZAP-70 is a 70 kD protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP-70 protein is expressed in leukemic cells of approximately 25% of Chronic Lymphocytic Leukemia (CLL) cases as well. ZAP-70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (ZAP-70 negative) and Ig-unmutated (ZAP-70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The ZAP-70 positive Ig-unmutated CLL cases have a poorer prognosis.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Tonsil, CLL/SLL

Visualization:Cytoplasmic and cell surface

Isotype:IgG

Immunogen:Recombinant fragment (around aa 200-400) of human ZAP70 protein

Ordering Information

USA International

Package Inserts

IFU-ZAP-70 ZR410 - IVD 0

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

Accept Reject

IFU-ZAP-70 ZR410 - RUO 0

Regulatory Notice

Accept Reject

SDS