Soft Tissue Pathology
    ZR381 Mouse Monoclonal

    This MAb reacts with a 58kDa protein identified as vimentin. It shows no cross-reaction with other closely related intermediate filament proteins (IFP s) such as desmin, keratin, neurofilament, and glial fibrillary acid protein. Anti-vimentin alone is of limited value as a diagnostic tool; however, when used in panels with other antibodies, it is helpful for the sub-classification of a given tumor. Expression of vimentin, when used in conjunction with anti-keratin, is useful when distinguishing melanomas from undifferentiated carcinomas and large cell lymphomas. All melanomas and Schwannomas react strongly with anti-vimentin. It labels various mesenchymal cells, including melanocytes, lymphocytes, endothelial cells, and fibroblasts. Non-reactivity of anti-vimentin is often considered more valuable than its positive reactivity since a few tumors do not contain vimentin, e.g., hepatoma and seminoma. Anti-vimentin is also useful as a tissue process control reagent.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Sarcoma or melanoma
    Immunogen:A recombinant fragment (around aa 2-466) of human Vimentin protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2672RL
    Classification IVD
    Catalogue Number Z2672RL
    Package Inserts
    IFU-Vimentin ZR381
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.