Formalin-fixed, paraffin-embedded human breast carcinoma stained with anti-VEGF antibody using peroxidase-conjugate and DAB chromogen. Note the cell surface and cytoplasmic staining of tumor cells

VEGF

General & Epithelial Markers

ZR389 Rabbit Monoclonal

This MAb recognizes proteins of 19-22kDa (reducing) and 38kDa-44kDa (non-reducing), identified as various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor (VEGF/VPF). It is highly specific to VEGF, which is a homodimeric, disulfide-linked glycoprotein with close homology to platelet-derived growth factor (PDGF). There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell-associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Tumor cells in astrocytomas, breast or ovarian carcinomas

Visualization:Cytoplasm, cell surface

Isotype:IgG

Immunogen:Recombinant fragment (around aa1-200) of human VEGFA protein (exact sequence is proprietary)

Ordering Information

USA International

Package Inserts

IFU-VEGF-ZR389- 0

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

Accept Reject

SDS