Urinary Pathology
    ZM204 Mouse Monoclonal

    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Bladder or urothelial carcinoma
    Visualization:Cytoplasmic and membranous
    Isotype:IgG2b /κ + IgG1 /κ
    Immunogen:Recombinant fragment (around aa 114-173) of human Uroplakin 1A (UPK1A) protein; recombinant fragment (around aa 109-229) of human Uroplakin 1B (UPK1B)
    Ordering Information
    Classification IVD
    Catalogue Number Z2522ML
    Classification IVD
    Catalogue Number Z2522ML
    Package Inserts
    IFU-Uroplakin ZM204
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.