Human lung adenocarcinoma stained with anti-TTF-1 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining of tumor cells.

TTF-1

Lung/Mediastinum Pathology

8G7G3/1 Mouse Monoclonal

TTF-1(Thyroid transcription factor-1) is a member of the NKX2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. TTF-1 is detected in primary lung adenocarcinomas and small cell carcinomas and is absent in colon and breast carcinomas. Staining with TTF-1 antibody is useful for distinguishing between tumors of lung and non-lung origin.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Normal thyroid or lung

Visualization:Nuclear

Isotype:IgG1 /κ

Immunogen:Rat TTF-1 recombinant protein

Ordering Information

USA International

Package Inserts

IFU-TTF-1 8G7G3/1 - IVD

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

Accept Reject

SDS