Breast Pathology
    ZR382 Rabbit Monoclonal

    TRPS1, named for its association with the autosomal dominant genetic disorder TRPS1, has been found to be a critical modulator in mesenchymal-to-epithelial transition during the development and differentiation of several types of tissue, including cartilage, bone, kidney, and hair follicle. Recently, TRPS1 was identified as a novel GATA transcriptional factor, functioning as an essential regulator for the growth and differentiation of normal mammary epithelial cells and possibly involved in the development of breast cancer. A recent study showed that TRPS1, which is highly expressed in triple-negative breast carcinoma (TNBC), was significantly higher than GATA3 expression in metaplastic (85% vs. 21%) and nonmetaplastic (86% vs. 51%) TNBC. Among non-breast tumors, TRPS1 is only expressed in some cases of lung squamous cell carcinoma, urothelial carcinoma (<2%), and ovarian adenocarcinoma. Therefore, TRPS1 has been found to be a highly specific and sensitive marker for all types of breast carcinomas, especially TNBC.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Normal breast or breast carcinoma
    Immunogen:Synthesized peptide corresponding to the C-terminus of human TRPS1 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2673RL
    Classification IVD
    Catalogue Number Z2673RL
    Package Inserts
    IFU-TRPS1 ZR382- 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.