Formalin-fixed, paraffin-embedded human squamous cell carcinoma stained with anti-Topoisomerase IIa antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells

Topoisomerase IIa

General & Epithelial Markers

ZR94 Rabbit Monoclonal

The topoisomerase II-α isoform is a 170kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-α is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-α is the predominant mechanism of resistance to several chemotherapeutic agents.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Tonsil

Visualization:Nucleus

Isotype:IgG

Immunogen:Synthetic peptide corresponding to Topo II α residues within aa1431-1531 of Topo II α

Ordering Information

USA International

Package Inserts

IFU-Topoisomerase IIa - ZR94 - IVD 0

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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IFU-Topoisomerase IIa - ZR94 - RUO 0

Regulatory Notice

Accept Reject

SDS