Topoisomerase IIa

    General & Epithelial Markers
    ZR94 Rabbit Monoclonal

    The topoisomerase II-α isoform is a 170kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-α is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-α is the predominant mechanism of resistance to several chemotherapeutic agents.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Immunogen:Synthetic peptide corresponding to Topo II α residues within aa1431-1531 of Topo II α
    Ordering Information
    Classification IVD
    Catalogue Number Z2404RL
    Classification IVD
    Catalogue Number Z2404RL
    Package Inserts
    IFU-Topoisomerase IIa - ZR94
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.